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  Postdoctoral Scientist in Organoid Multiomics  

  University of Oxford

  [fulltime parttime temporary] - Oxford

  Posted: 06/10/2025

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  We are looking for an enthusiastic post-doctoral scientist to work in... Read More

  We are looking for an enthusiastic post-doctoral scientist to work in our research team. You will be based in the Old Road Campus Research Building in the tumour evolution and cell identity laboratory, as your normal place of work. You will join the SMOC (Stem cell signatures of Mutational Order in Colorectal Cancer) study, a Cancer Research UK–funded programme led from the University of Oxford. The project aims to uncover how the sequence of genetic mutations in colorectal cancer drives changes in stem cell identity, epigenetics, tumour–microenvironment interactions, and therapy response. You will lead the multiomic and phenotypic profiling of gene-edited and patient-derived organoids in the SMOC study. This will involve bulk and single-cell RNA-seq, ATAC-seq, DNA methylation profiling, and proteomics, integrated with high-content live-cell imaging datasets (SPOT/SAM analysis). You will develop pipelines to link genotype, transcriptome, epigenome, and morphodynamic phenotypes, and use these to explore how mutational order shapes stem cell identity, heterogeneity, and therapy response. The role offers extensive opportunities for collaborative and interdisciplinary science, working closely with experimental biologists, computational modelers, and clinical partners. You will be positioned to drive mechanistic insights and translational applications, with the chance to lead high-profile publications. About you You will hold (or be close to completing) a PhD in molecular biology, genomics, bioinformatics, or a related field. You will bring strong experience in single-cell and/or bulk multiomic technologies, with skills in data analysis and interpretation. Familiarity with colorectal cancer biology, epigenetics, or advanced imaging/phenotyping would be an advantage. You will have a strong publication record, excellent communication skills, and the ability to work across disciplines. A collaborative mindset and the drive to integrate complex data into novel biological insights will be key. This full-time/part-time post is available immediately fixed-term for six years in the first instance. Application Process Read Less

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• 

  Research Assistant  

  University of Oxford

  [fulltime] - Oxford

  Posted: 30/09/2025

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  We are seeking a Research Assistant to join the newly established rese... Read More

  We are seeking a Research Assistant to join the newly established research group led by Dr Malcolm Sim, which focuses on understanding Killer cell Immunoglobulin-like Receptors (KIR) and their role in human disease. KIR are a family of natural killer (NK) cell receptors that bind MHC-I molecules and are linked to a range of conditions including cancer, viral infection and pregnancy disorders. The group is working to uncover how peptides presented by MHC-I regulate KIR recognition and NK cell effector function, using novel methods to define KIR peptide-specificity and generate tools for further study. In this role, you will use peptide libraries and KIR binding assays to define specificity across multiple MHC-I alleles, and perform functional experiments with primary NK cells to validate ligands. Your work will primarily involve sterile tissue culture, flow cytometry and molecular biology. There will also be scope to expand the project, developing novel high-throughput screening methods in collaboration with Dr Ricardo Fernandes at the Chinese Academy of Medical Sciences Oxford Institute. You will take responsibility for planning and carrying out experiments, analysing and presenting results, and contributing to publications and reports. You will work closely with colleagues within the group and across related research teams, supporting shared activities and helping to maintain the smooth running of the laboratory. The role also offers opportunities for presenting your work at meetings and for engaging in departmental activities. It is essential that you hold a degree in a relevant biomedical science area, with good knowledge of immunology, including NK cell biology, receptor–ligand interactions, MHC-I structure and antigen presentation. You will need proven laboratory experience, ideally with molecular biology, proteomic and immunological techniques such as flow cytometry, and should be confident working with experimental protocols and adapting them where needed. Experience in sterile tissue culture and cellular immunology techniques would be a strong advantage. Strong communication skills, including the ability to present results clearly and contribute to publications, are essential. An MSc in a relevant field, significant experience with multi-parameter flow cytometry, or authorship on a scientific publication would be desirable. Read Less

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