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• 

  Postdoctoral Scientist  

  Medical Research Council

  [fulltime] - Cambridge

  Posted: 17/09/2025

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  Key responsibilities:Within the overall direction of the programme, th... Read More

  Key responsibilities:Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan. To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor.To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.To enhance your research and generic skills through a tailored development programme. Working relationships:You will report to Dr Anne Bertolotti and will interact and collaborate with other Postdoctoral Scientists, Research Support staff and students, not only in your group, but also across the LMB and with external groups as necessary.Additional information:This is a three-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including:
  • MRC training courses.
  • External training and personal development courses.
  • One-to-one training with your Supervisor and other Scientists.You will commit to undertaking the following:
  • Developing and following a personal development plan.
  • Attending training courses.
  • Identifying additional training which will support you to develop your career. /*generated inline style */ Person Specification Academic qualifications:These should include a PhD in biochemistry/ structural biology or due to complete PhD within 6 months.Technical skills and expertise:Essential: Experience of and ability to perform techniques relevant to the project. Experience in structural biology including CryoEM is essential. Experience in protein expression and purification in diverse systems is essential.Desirable:
  • An interest in signalling and/or stress response/protein quality control.
  • An interest in protein phosphorylation.
  • An interest in enzymology and small molecule inhibitors.Track record of research:This will include achievements, and contributions to published papers. Read Less

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• 

  Maintenance Technician x 2 LMS 2693  

  Medical Research Council

  [fulltime] - London

  Posted: 17/09/2025

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  Key responsibilities:to be responsible for providing electrical and/or... Read More

  Key responsibilities:to be responsible for providing electrical and/or mechanical reactive maintenance (RM) on all plant systems and services. You will also help to manage and deliver project worksto undertake works on behalf of the Estates team including supervising external service providers and contractorsto liaise with end users to plan in repair works or project works as required.to be responsible for interrogating the computer-controlled Building Management Systems (BMS) to monitor and identify fault diagnostics, taking the appropriate action to resolve theseto undertake on-call duties approximately 6-8 weeks per annum, responding to callouts when off-siteWorking relationships: You will report to the Hard Services Manager and will be part of the Estates team within the wider LMS Research Environment function.You will interact with members of the LMS, effectively communicating with them to establish their needs and communicate these needs both orally and through written specifications to those carrying out the work. You will also work closely with other members of the Research Environment team to coordinate works with minimal disruption to science Health & Safety, Lab Services, Soft ServicesYou will interact with external service providers and contractors. /*generated inline style */ Person Specification Education / qualifications / training required:Essential:Completed a recognised electrical or mechanical apprenticeship or hold the equivalent qualificationsDesirable:Formal Health & Safety (H&S) qualifications and ability to undertake risk assessments
  Previous work experience required: Essential:Experience of working in a complex building with responsibility for electrical and/or mechanical systems.Experience of supervising external contractorsDesirable:Experience in a scientific environment
  Knowledge and experience: Essential: Good working knowledge of engineering services coupled with a good understanding of all aspects of building maintenanceAn understanding of work-related H&S risks, and how to mitigate against the risksExperience of using a BMS systemAn understanding of HVAC systemsDesirable: An understanding of statutory maintenance requirementsExperience of estimating correct quantity of materials to complete maintenance and/or project works
  Personal skills / behaviours / qualitiesIT skillsEssential: Competent IT skills including use of Microsoft OfficeCompetent working with handheld devices (iPhone/tablets etc) and “smart” technologyCommunications skillsEssential: Ability to effectively communicate with users and service providers, establishing the needs of the users and communicating these needs both orally and through written specifications to those carrying out the workExcellent interpersonal skills with the ability to work closely and effectively with staff at all levelsAbility to listen to others, understand and interpret their views, analyse, and provide advice/solutionsOrganisation skills and initiativeEssential: Ability to plan and prioritise work without or under limited supervisionAbility to use initiative when requiredAbility to adapt, as the workload is varied and priorities can change at short notice, which may require working outside normal working hours (overtime is payable)Ability to work flexibly, as on-call cover duties need to be undertakenTeam workingEssential: Ability to work as part of a team or independentlyAbility to work under pressure but constructively, collaboratively, and productively with colleagues at all levels within the LMS and externally /*generated inline style */ Read Less

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• 

  Animal Technician  

  Medical Research Council

  [permanent fulltime parttime] - Didcot

  Posted: 17/09/2025

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  View Vacancy -- Animal Technician - MLC 2707 Open Date 29/08/2025, 10... Read More

  View Vacancy -- Animal Technician - MLC 2707 Open Date 29/08/2025, 10:15 /*generated inline style */ Close Date /*generated inline style */ 21/09/2025, 23:55 /*generated inline style */ Research Institute MRC Mary Lyon Centre /*generated inline style */ Research Institute / Unit Information The (MLC) is located in an expanding science and innovation campus in Oxfordshire and is an internationally renowned centre at the forefront of genetics research. As the hub of the new National Mouse Genetics Network, the specialist facilities and capabilities of the MLC support a number of research groups across the UK to accelerate our understanding of human diseases, such as cancer, developmental disorders and neurodegeneration. /*generated inline style */ UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at
  
  /*generated inline style */ Band MRC - 5 /*generated inline style */ Location Harwell Campus, Oxfordshire /*generated inline style */ Salary £30,911 - £32,843 per annum, dependent on skills and experience, pro rata if part time /*generated inline style */ Contract Type Permanent /*generated inline style */ Job Type Technical & Scientific Professionals /*generated inline style */ Full Time / Part Time Full or Part Time options /*generated inline style */ Job Description Overall Purpose: We are looking for an Animal Technician to work in the Mary Lyon Centre (MLC) team to carry out high quality husbandry and experimental procedures to fulfil scientific needs. This includes working under Home Office licensing (The Animals (Scientific Procedures) Act 1986, amended 2012) to carry out procedures to advance medical research, including meticulous record keeping of all animal-related work. In addition this post will need to ensure that the needs of the animals are met in terms of clean cages, food, bedding and health checks.Main Duties/Key Responsibilities:Carrying out husbandry duties for genetically altered mice, including cage changing, weaning, breeding, randomisation of mice into studies and taking ear biopsiesChecking the health and welfare of mouse stocks and addressing their welfare needsAttending meetings with researchers to update them on genetically altered stocks, and to discuss future projects and breeding strategiesProviding procedural services, this will include a variety of procedures such as dosing, taking blood samples, and phenotyping testsComputerised record keepingReading and adhering to standard operating procedures (SOPs) and risk assessmentsWorking weekends on a rota basisWorking Relationships: The post-holder will be a member of a team working under the supervision of a line manager and ward supervisor. Animal technicians work in teams and support each other to ensure that all the work is carried out to a high standard. Good communication and the ability to work with others is essential. The post-holder will also liaise with members of other teams, including MLC maintenance, phenotyping and necropsy, and with teams of researchers.Additional Information: Must be able to work overtime to cover animal requirements.This role is offered as a full time position (36 hours per week) however part time hours of 25 - 30 hours will be considered.
  /*generated inline style */ Person Specification Education/Qualifications/Training Required: Essential:5 GCSEs at grade C or aboveDesirable:Home Office LicenceFurther qualification in biology or chemistryPrevious Work Experience Required: Essential: Experience of working in a busy environmentDesirable: Experience of working with laboratory animalsExperience in assessing and treating health concerns in animalsExperience of working in a laboratory environment, including working to SOPs and risk assessmentsExperience in procedures such as dosing or phenotypingKnowledge and Experience: Essential:Genuine interest in the welfare of animalsBasic computer skills, including the ability to use digital record keeping systems and common software packages (for example, Excel) Desirable:Ability to train other members of staffExperience in animal husbandryPersonal skills/Behaviours/Qualities: Essential: Excellent attention to detailAbility to work as part of a team or autonomously when requiredSelf-motivated and positive influence on other team members /*generated inline style */ Read Less

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• 

  MRC Postdoctoral Research Scientist LMS 2711  

  Medical Research Council

  [fulltime] - London

  Posted: 17/09/2025

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  Overall purpose:The Single Molecule Imaging Group works at the interse... Read More

  Overall purpose:The Single Molecule Imaging Group works at the intersection of single molecule imaging, biophysics, mechanobiology and cellular biology to explore the mechanisms of epigenetic regulation. The group uses single-molecule fluorescence and mechanical manipulation with optical tweezers to analyse the interaction of proteins and DNA/RNA, elucidate their dynamics and elucidating molecular mechanisms. We use additional interdisciplinary approaches to investigate these mechanisms across scales (from molecules to cells).We are seeking a talented postdoctoral research scientist with a background in structural biology and biochemistry. The post holder will be a key member of our team investigating the structural mechanism of ATP-dependent chromatin remodellers. The work will involve the expression and purification of chromatin remodelling complexes, with the aim of obtaining high-resolution single-particle cryo-electron microscopy structures to reveal functional mechanistic insights into how these chromatin remodelling complexes operate. The successful candidate will have an opportunity to work in a diverse team that brings together physicists, chemists and biologists to work on problems that are key to human health. There are excellent opportunities for development and training. We offer excellent mentoring and support to reach your career goals. The post holder will have the opportunity to liaise with an extensive network of collaborators, attend scientific conferences, and publish the results of their work in leading journals.
  Key skills:Background in Structural biology and BiochemistryExperience with expressing and purifying multi-subunit protein complexesExperience of performing cryo-electron microscopy experimentsExperience in analysing structural data to elucidate biological mechanismsWorking knowledge of protein-DNA interactionsMain Responsibilities:To use insect-cell based systems to over-express chromatin remodelling complexesTo purify chromatin remodelling complexes for structural, biochemical, and single-molecule imaging studiesTo perform single-particle cryo-electron microscopy-based experiments to obtain high resolution structures of chromatin remodelling complexesTo interoperate structural data to uncover functional mechanisms of how these chromatin remodellers functionTo prepare work for publication and grant submissionsTo present at seminars and conferences, as necessaryTo co-supervise MSc and PhD studentsWillingness to work out of normal working hours (including weekends) if the requirements of the project demandTo contribute to the smooth running of the Group’s/Unit’s laboratories and, facilities with other scientists, technicians and students within the laboratoriesTo assist in the supervision of undergraduate and postgraduate research students and research assistants as requiredTo comply with the Institute, College, Division, and Unit safety practices and to attend courses on safety when appropriateAny other duties as may be deemed reasonable by Head of group as well as Head of Division /*generated inline style */ Person Specification Education / Qualifications / Training required (will be assessed from the application form): Essential:PhD in Structural Biology and/or Biochemistry (or a closely related discipline) 
  Knowledge and experience (will be assessed from the application form and at the interview):Essential: Excellent skills in structural biology and biochemistryPrevious experience with using insect cell-based systems to express multi-subunit protein complexes, and experience with protein purificationPrevious experience in grid preparation for cryo-electron microscopy experimentsPrevious experience of using cryo-electron microscopesPrevious experience in cryo-electron microscopy data analysis and model building with a track record of relevant publications and presentationsExcellent written communication skills in English and the ability to write clearly for publication
  Desirable:Previous experience with working with ATP-dependent chromatin remodelling complexesProven experience collaborating with single-molecule biophysicists, resulting in a strong track record of publicationsPersonal Skills / Behaviours / Qualities (will be assessed at the interview):Essential: Ability to conduct reproducible researchAbility to conduct a detailed review of recent literatureAbility to develop and apply new conceptsCreative approach to problem-solvingExcellent verbal communication skills in English and the ability to deal with a wide range of peopleAbility to direct the work of a small research team and motivate others to produce a high standard of workAbility to organise own work with minimal supervisionAbility to prioritise own work in response to deadlinesAdvanced computer skills, including word-processing, spreadsheets and the internetWillingness to work as part of a team and to be open-minded and cooperativeFlexible attitude towards workDiscipline and regard for confidentiality and security at all timesWillingness to undertake any necessary training for the role /*generated inline style */ Read Less

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