Principal Research Scientist - In Silico Biologics Design - Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry\\\'s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.
The Principal Scientist In Silico Biologics Design will provide world class expertise in machine learning to drive the establishment of robust in silico methodologies that integrates computational predictions with empirical laboratory data to revolutionise the design of our class-leading T-cell receptor (TCR) drugs. Using our wealth of structural data, combined with further in-house and public domain data sets, the successful applicant will develop ML algorithms to impact the design of future drugs. This is an exciting technology-focussed role so innovation, execution and collaboration are key factors for success. Working closely with the In Silico and automation teams within Protein Engineering, you will provide scientific and technical leadership relating to machine learning that will ultimately result in further progression of our growing pipeline of first-in-class drugs to benefit patients. With our successful launch in 2022, of the world\\\'s first TCR based medicine, KIMMTRAK, which is also the first launched treatment for any solid tumour, you will be joining us at the most exciting time in our history, and be part of a team that values innovation, trust and collaboration.
KEY RESPONSIBILITIES
* To develop and assess advanced machine learning (ML) models for novel antibody and TCR drug candidate optimisation and, looking to impact de novo drug design in the future
* Utilise our extensive in-house structural and specificity data sets to extract further value
* Work with colleagues across Research to identify training data from the public domain and help shape the development of our in-house data sets to support the optimisation of ML algorithms
* Drive the establishment of virtual screening tools including:
o Protein structure prediction
o Affinity prediction
o Peptide human leukocyte antigen (pHLA) specificity prediction
o Developability prediction
* Assist with TCR library design for multifactorial lead optimisation
* Work with interdisciplinary teams across structural biology, next-generation sequencing (NGS), and bioinformatics and data science to integrate machine learning into TCR discovery and optimisation.
* Work with scientists to validate and integrate new methodologies into existing architecture.
* Promote utilisation of ML algorithms among colleagues and mentor and train others in their deployment
* Present research outcomes at all levels, including Protein Engineering lab meetings, Research leadership team meetings, other governance meetings and at external conferences
PERSON SPECIFICATION
Experience & knowledge
Essential
* Demonstrated ability to build and evaluate machine learning models
* At least 8 years of experience in antibody, TCR or biologics design, evidenced by a strong publication record.
* Proficiency with protein ML models such as AlphaFold, ESMFold, RFdiffusion, MPNN
* Advanced Python programming skills, focusing on data science and machine learning.
* Managed sizeable research projects, understanding the wider implications of project outcomes and strategic objectives.
* Demonstrates effective coaching skills and brings vision and strategy to life for others.
* Exceptional communication skills.
* Demonstrated ability to build and sustain networks and external collaboration with scientific leaders in the field.
Desirable
* Expertise in structural biology and modelling
* Experience in NGS analysis.
* Experience with biologics data management software including Genedata and in handling and integrating large-scale biological datasets from different sources.
* Familiarity with deploying and managing computational workflows on cloud platforms (e.g. AWS)
Education & qualifications
* PhD in Computational Biology, Computational Chemistry, Bioinformatics, or related discipline.
Scientist - Infectious Diseases - Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry\\\'s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients\\\' lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
The primary purpose of this role is to contribute to cross functional efforts focused on applying the ImmTAX® platform or other modalities to the development of novel treatments for chronic infections, including HIV and HBV and EBV-associated diseases. The team is involved in multiple stages of the drug discovery and development process, from target discovery all the way to clinical trials. Examples of key preclinical research are published in Yang H et al., Mol Ther. 2016; 24,11; Fergusson J et al., Hepatology 2020; 72,5; Wallace Z et al., Mol Ther 2024; 32, 678.
The postholder will plan, design and execute experimental investigations to support the advancement of the Company pipeline, processes and technology capabilities, with guidance from their manager, ensuring that project goals are met within time and budget constraints. They will be expected to demonstrate technical proficiency, rigour in assessing their own data and that of others, scientific creativity and independent thought. This position requires participation and presentation of results at internal meetings, sharing information learned at external scientific meetings and establishing productive relationships with colleagues across Research and other departments.
Key Responsibilities:
* With instruction and guidance from manager - plan, design, and execute assignments to meet project goals within defined timeframes
* Execute experiments to address key scientific questions and enable project progression, utilizing range of molecular and cellular techniques including some of the following: NextGen sequencing, DD-PCR, qPCR, cell culture, flow cytometry, ELISpots, ELISAs,
* Some work will be conducted in a containment level 3 (CL3 facility) and will require handling of human viruses
* Analyse data, interpret results, and make recommendations
* Proactively expand scientific/technical knowledge in relevant fields including HIV/HBV/EBV related disease biology and drug development through review of scientific literature/ conference updates, peer to peer mentoring, and attendance at seminars/conferences in line with company strategy
* Work effectively in a matrixed team structure and as part of cross functional teams
* Participate and present results at internal meetings
* Establish relationships and possible collaborations within and outside of the company
Education, Experience and Knowledge:
Essential Qualifications:
* PhD in molecular biology, cell biology, genomics, virology, immunology, or related discipline and 0-2 years related experience
* Alternatively, a BSc or MSc with significant work experience in relevant scientific areas
* Worked in a bench-based laboratory environment and proficient inthe following key techniques:
o molecular techniques including some of the following: Droplet Digital PCR, NextGen sequencing, Genomics/Transcriptomics, PCR, Mutagenesis, qPCR
o Culturing primary cells and/or cell lines
Preferred Qualifications:
* Knowledge/expertise of Immunology/HIV/HBV/EBV
* Flow cytometry, ELISAs, ELISpots
* Viral integration site analysis
Associate Process Development Scientist, Downstream - Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry\\\'s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients\\\' lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
To conduct experimental investigations to drive the downstream process development of emerging drug candidates, supportive reagents and successful establishment of production processes for manufacturing and clinical development. Protein purification is core to this role, requiring an understanding of protein characteristics to utilise column chromatography and separation techniques along with analytical assessments of purity, using methods such as SDS-PAGE and HPLC. The job requires a strong team player capable of following instructions with a drive for learning and developing knowledge and experience in downstream process development. Robust record-keeping and regular reporting of results are essential.
KEY RESPONSIBILITIES - ALL SCIENTISTS
* Conducting experiments, observing, interpreting, and responding to results.
* Following experimental protocols and writing reports
* Maintaining and increasing technical knowledge in relevant fields through self-study, observation and attending relevant conferences or training courses.
* Maintaining accurate records of all work by completing laboratory notebook on time, following company procedures.
* Ensuring laboratory equipment is operated in accordance with safety and risk guidelines, acting promptly to report any faults or problems.
* Operating in accordance with the Company\\\'s Health and Safety policies, especially within a laboratory environment.
SPECIFIC RESPONSIBILITIES
* Experiments: running pre-established experimental investigations, with guidance from line managers, a mentor or colleagues. Reviewing data with line manager or colleagues before next steps.
* Priorities: working to agreed experimental priorities and deadlines; raising issues or concerns with managers or colleagues so that these can be addressed
* Technical knowledge: actively developing own knowledge, drawing on the experience of others and self-learning
* Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard, checking with a mentor or colleagues if unsure
* Laboratory equipment: attending training on the use of technical instruments, using equipment appropriately, correctly and tidily; owning and maintaining assigned items of equipment
* Reporting: communicating and presenting research findings at meetings with colleagues and line manager. Regular reporting on progress of work verbally and in writing. Protocols and reports to be written and reviewed to meet the Immunocore Quality system.
* Health & Safety: compliance with all H&S requirements, attending appropriate training programmes
EXPERIENCE AND KNOWLEDGE
Essential
* Operated in a bench-based microbial or mammalian expression, biochemistry, molecular biology, analytical or bio-pharmaceutical laboratory environment with experience or familiarity in these areas:
- Protein purification
- Routine microbial culture operations
- Aseptic techniques
- Basic protein biochemistry and/or molecular biology
- Competent in the safe use of general laboratory equipment
* Recorded results and information in a concise, accurate and timely way, and in compliance with agreed standards
* Learnt about new practices through observation, self-learning and an enquiring mind
* Worked and contributed actively in a diverse team environment
Desirable
* AKTA purifications and method design
* Molecular biology skills
* Biophysical characterisation of proteins
* Mammalian expression
* An awareness of cGMP and biopharmaceutical manufacturing requirements
* DoE experience
* Able to interpret results with minimum guidance
* Proficient in general laboratory analysis software
* Implemented or influenced best lab practice
* Worked in an industrial/biotechnology laboratory environment
EDUCATION & QUALIFICATIONS
* Essential: GCSE in mathematics, English and science
* Desirable: BSc. or MSc. In protein engineering, microbiology, biochemistry, molecular biology or related discipline
Process Development Scientist, Downstream - Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry\\\'s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients\\\' lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
To conduct and design experimental investigations to drive the downstream process development of emerging drug candidates, supportive reagents and successful establishment of production processes for manufacturing and clinical development. Protein purification is core to this role, requiring knowledge and understanding of protein characteristics to implement robust column chromatography and separation techniques along with analytical assessments of purity, using methods such as SDS-PAGE and HPLC. The ability to work independently, as well as part of a team and to tight deadlines is essential. Robust record-keeping and strong communication skills are also required. The job also involves interaction and document/technical reviews with external CDMO partners to support successful GMP manufacturing and regulatory compliance.
KEY RESPONSIBILITIES - ALL SCIENTISTS
* Conducting experiments, observing, interpreting, and responding to results.
* Following experimental protocols and writing reports
* Planning experiments and carrying out priorities, with guidance from line manager or other team members
* Maintaining and increasing technical knowledge in relevant fields through self-study, observation and attending relevant conferences or training courses.
* Maintaining accurate records of all work by completing laboratory notebook on time, following company procedures.
* Ensuring laboratory equipment is operated in accordance with safety and risk guidelines, acting promptly to report any faults or problems.
* Operating in accordance with the Company\\\'s Health and Safety policies, especially within a laboratory environment.
SPECIFIC RESPONSIBILITIES
* Experiments: Independently running pre-established lines or areas of investigation, seeking guidance and support from colleagues and line managers as required and to confirm experimental direction.
* Priorities: Planning and working to agreed experiment deadlines, schedules and objectives, alerting managers and colleagues to risks and deviations that may impact meeting the goals, so that these can be addressed.
* Technical knowledge: Actively developing own knowledge, drawing on the experience of others and self-learning, practicing and sharing acquired skills that may benefit the team with colleagues and managers.
* Laboratory records: Ensuring that all records and information are up to date, on time and recorded to the correct standard, seeking support when uncertain on how to complete these satisfactorily.
* Laboratory equipment: Attending training on the use of technical instruments, using equipment appropriately, owning and maintaining assigned pieces of equipment.
* Reporting: Presenting research, data and findings to colleagues at group/department team meetings. Regular reporting on progress of work verbally and in writing to line manager. Protocols and reports to be written and reviewed to meet the Immunocore Quality system.
* Health & Safety: Compliance with all H&S requirements, attending appropriate training programmes.
EXPERIENCE AND KNOWLEDGE
Essential
* Worked in a bench-based microbial or mammalian expression, biochemistry, molecular biology, analytical or bio-pharmaceutical laboratory environment gaining the following experience:
- Aseptic techniques
- Microbial manipulations, including transformation and culture
- Recombinant protein expression
- Protein purification techniques and operation of AKTA purification equipment
- Protein characterisation, including SDS-PAGE
- Competency in the use of general lab equipment and software
* Recorded results in a concise and timely way and in compliance with agreed standards
* Able to design experiments and interpret results with minimal guidance
* Learnt about new practices based through observation, self-learning and an enquiring mind
* Worked and contributed actively in a diverse team environment
Desirable
* Molecular biology skills
* Biophysical characterisation of proteins
* Analysing protein-protein interactions, using Biacore or Octet
* Troubleshooting protein purification or recombinant protein expression
* Mammalian expression
* An awareness of cGMP and biopharmaceutical manufacturing requirements
* DoE experience
* Lab management and implementing/supporting best practice
* Presented scientific findings and progress to internal and external audiences.
* Worked in an industrial/biotechnology laboratory environment
EDUCATION & QUALIFICATIONS
* BSc. or MSc. Or PhD in protein or biochemical engineering, biochemistry, microbiology, molecular biology, or related discipline
* Desirable: Relevant industrial or post-qualification academic experience
Senior Scientist I - Characterisation | CMC - Oxford Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry\\\'s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients\\\' lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
To characterise the companies biotherapeutic recombinant T-cell receptor based and related molecules using a wide variety of protein characterisation and mass spectrometry methods. To contribute to the development of characterisation methods for the company\\\'s biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass spectrometry analysis.
KEY RESPONSIBILITIES
* Supporting drug substance and drug product impurity characterisation and identification
* Performing protein sequence and post translational modification identification, including glycosylation analysis.
* Supporting drug substance and drug product process development by performing characterisation of process intermediates
* Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis
* Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
* Contribute to writing study protocols and reports.
* Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
* Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
* Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department. May also act as a mentor to other colleagues, sharing scientific knowledge. Providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the department.
* Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
* Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively.
* Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.
* Adhere to safe working practices in laboratories according to Immunocore EHS policies.
PERSON SPECIFICATION
Experience & knowledge
Essential
* Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
* Experience of glycosylation analysis of recombinant proteins or antibodies.
* Independently coordinated extensive testing of protein biomolecules.
* Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
* Understanding of expected post-translational modifications in biological systems.
* Worked in a bench-based biopharmaceutical laboratory environment.
* Established as an expert amongst peers in one or more of the following areas:
o electrophoretic
o chromatographic
o mass spectrometry
* Experienced in assay development
* Familiar with biopharmaceutical stability study principles and interpretation thereof
* Worked and contributed actively in a diverse team environment
* Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
* Presented detailed scientific findings and papers to internal and external audiences
Desirable
* Experience of glycosylation analysis of recombinant proteins or antibodies
* Experience with late stage/commercial biopharmaceutical assay development and characterisation
* Familiar with the principles of Good Manufacturing Practise (GMP)
* Presented at external conferences
* Led a small project team, formally or informally, through a change in practice including project management
* Understanding of analytical requirements to support materials for use in clinical trials
Education & qualifications
* Essential: BSc. Or MSc. in biochemistry, biotechnology or related discipline
* Desirable: PhD in related discipline
