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  • Introduction to roleAre you ready to turn complex cross-border data ru... Read More
    Introduction to roleAre you ready to turn complex cross-border data rules into practical pathways that unlock AI-driven drug discovery? Do you thrive at the intersection of scientific data, regulatory interpretation, and operational execution where your decisions enable researchers to move faster with confidence?About the Beijing AI Center The Beijing AI Center is a new strategic investment by AstraZeneca to accelerate drug discovery through AI. The center brings together AI researchers, computational scientists, and platform engineers to apply foundation models, agentic AI, and large-scale scientific computing to real R&D problems. Situated in one of the world’s most dynamic AI talent markets, it operates at the intersection of biologics discovery, computational chemistry, and AI-driven drug discovery. The center is structured around three pillars: Discovery verticals (therapeutic design and preclinical predictions), Data & AI Platforms, and Ecosystem Partnerships with leading Chinese academic institutions and AI companies. Accountabilities:This role is the transfer-readiness owner for enabling cross-border scientific data access into China for the Beijing AI Center. It addresses the operational gap that exists before formal approval:the preparation work needed to ensure incoming data requests are assessed against sending-jurisdiction restrictions, appropriately scoped, decision-ready, and auditable. The primary data flow is global AstraZeneca R&D into China. The Beijing AI Center needs access to molecular libraries, assay data, omics reference sets, compound data, clinical datasets, and other scientific assets from AstraZeneca's global portfolio to power AI-driven drug discovery. The regulatory challenge sits largely on the sending side — determining what can be transferred or accessed given restrictions(e.g., DOJ EO 14117) on bulk sensitive personal data, export control considerations, and AstraZeneca's internal data governance policies — as well as ensuring appropriate classification and protection once data arrives in China. This is not a final approver role. Rather, it is a dedicated role focused on first-pass triage, provenance tracing, metadata review, annotation coordination, evidence package preparation, and process tracking. The role is intended to reduce the fragmented burden currently carried in an ad hoc way by scientists, business teams, and SMEs, especially for China-related or otherwise non-standard requests. The immediate priority is China data transfer, but the role should be designed for broader global cross-border sharing. The role will help stabilize the current interim process while building a more scalable and consistent operating model that can inform a future integrated solution. This role sits at the intersection of scientific data, compliance preparation, and operational execution. It requires enough breadth across R&D data domains and cross border transfer regulations to work effectively across biologics, small molecules, and safety-related contexts, while also knowing when to pull in domain SMEs, the R&D Data Office, Privacy, Compliance, and designated approvers. What You Will Do Transfer Readiness & First-Pass Triage Design and own the intake process for cross-border data sharing requests — including request workflow, queue management, prioritization criteria, and routing logic Own first-pass intake triage for cross-border data sharing requests, with mandatory review for China-related or non-standard requests and simplified routing for straightforward requests Check request completeness including business justification, recipient, intended use, data source, format, and baseline supporting information Provide first-pass triage recommendation on whether a request is likely in scope, out of scope, or ambiguous, while preparing the supporting rationale for formal review Escalate ambiguous or higher-risk cases to the R&D Data Office, SMEs, and designated approvers with clear questions and structured evidence Manage DOJ compliance assessment for CRO ordering — evaluating data shared with China-based CROs against EO 14117 thresholds and transaction type classifications Provenance Tracing, Annotation & Metadata Coordination Lead provenance tracing for legacy or incompletely documented datasets by reviewing records, systems, and source history across relevant platforms Coordinate metadata collection and completion needed to support transfer assessment and downstream usability Support annotation and evidence preparation so datasets are sufficiently described, contextualized, and auditable before review Partner with bioinformatics and scientific SMEs to resolve data history, source, ownership context, and metadata gaps Differentiate between new / well-annotated data and legacy / incomplete data, applying a lighter path for the former and a deeper tracing effort for the latter Data Curation & China-Readiness Curate and annotate scientific data assets (e.g., structure data in GDB) to ensure datasets are complete, well-structured, and usable for Beijing AI Center workstreams Perform structure data curation supporting both Biologics Engineering and Small Molecules domains Apply appropriate ontologies, standardized formats, and metadata tagging to support cross-domain reuse and AI/ML consumption Partner with domain scientists to resolve data quality, completeness, and annotation gaps prior to transfer Workflow Management & Process Improvement Prepare structured evidence packages for Data Owners, Data Stewards, and designated approvers so requests are decision-ready before formal review Track the interim data sharing process from intake through approval, transfer execution, validation, and closure Act as process coordinator / tracker during transfer execution, following up on dependencies and ensuring documentation is complete, without taking over technical execution tasks Capture recurring issues, requirements, and control points from the interim process to support the design of a future integrated data sharing solution Improve templates, checklists, trackers, SOP inputs, and audit-readiness practices over time Cross-Functional Partnership & Training Work with the R&D Data Office to identify what data is likely in scope or out of scope across different workstreams Partner with Privacy and Compliance to ensure transfer assessments reflect current privacy requirements and that escalation pathways are well-defined Build practical understanding of the systems used across biologics, small molecules, and safety and how data is stored, annotated, accessed, and extracted from separate systems Provide guidance to business and scientific teams on transfer readiness expectations, required metadata, and supporting information Reduce ad hoc burden on scientists and business teams by becoming the clear owner of the manual preparation work needed before approval Essential Skills/Experience:Education: BSc/MSc, or equivalent advanced training in life sciences, bioinformatics, data science, information management, or a related field preferred Years: Significant experience in pharmaceutical or biotech R&D data environments, typically 4+ years post-qualification Domain breadth: Experience spanning multiple stages of drug discovery and development and/or multiple scientific data domains (e.g., discovery, preclinical, clinical, post-market) Core expertise: Practical experience in one or more of: scientific data management, data stewardship, data governance, research data operations, data privacy operations, or regulated data workflows Cross-border data work: Experience assessing, preparing, or supporting cross-border data sharing decisions — particularly understanding sending-side regulatory requirements and how to structure compliant access Governance preparation: Experience preparing information for governance, compliance, or approval decisions — not only executing downstream data processing Skills Regulatory literacy: Ability to understand and operationalize requirements from multiple regulatory frameworks (US DOJ, internal policy) at a working level — sufficient to perform first-pass assessment and know when to escalate to Legal DOJ EO 14117 familiarity: Working understanding of the DOJ's bulk sensitive personal data framework — including threshold categories, covered transaction types, prohibited vs. restricted classifications, and exemption pathways — is strongly preferred Domain-specific data skills: Familiarity with structural biology/chemistry data, molecular data formats, and scientific annotation standards (e.g., structure-activity relationships, compound descriptors, GDB or equivalent platforms) Domain versatility: Ability to work across biologics, small molecules, clinical, omics, imaging, and safety-related data contexts with enough breadth to assess data content and origin Analytical rigor: Ability to assess data volumes against thresholds, map data to jurisdictions, evaluate exemption applicability, and structure clear decision-support documentation Operational discipline: Strong documentation rigor, process discipline, and audit mindset Stakeholder management: Credibility across scientists, AI researchers, SMEs, legal/privacy teams, and governance approvers — able to translate between technical data needs and compliance requirements Problem-solving: Ability to identify alternative access patterns, minimization strategies, and creative solutions when straightforward transfer is restricted Systems literacy: Enough familiarity with data platforms to understand how data is stored, what metadata exists, and how to assess data content without requiring deep technical data engineering skills China / Cross-Border Context China data classification: Familiarity with China's DSL data classification framework and what obligations apply to data once it enters China is preferred Global matrixed environment: Ability to work effectively across China and non-China stakeholders — coordinating with US, EU/UK, and global teams on data access requests Mindset Comfortable with ambiguity: Regulatory frameworks are evolving (particularly DOJ implementation guidance); this role will often work with emerging interpretations, grey areas, and imperfect precedent Low ego, high impact: Willing to do detailed threshold calculations, jurisdiction mapping, and documentation work that enables better decisions at scale Enablement-oriented: Approaches compliance as a problem to solve, not a gate to close — actively seeks minimization strategies, alternative access patterns, and creative compliant solutions to get researchers what they need Structured and practical: Able to turn regulatory requirements and fragmented information into a clear, repeatable operating process Collaborative and credible: Able to work across scientific, AI, legal, privacy, and governance stakeholders with equal fluency Judicious and disciplined: Understands the difference between first-pass triage and final approval accountability Time zone flexibility: Comfortable working across US/UK and China hours as needed to support Beijing AI Center stakeholders Desirable Skills/Experience:Education: PhD within relevant field Experience in both discovery-stage and later-stage R&D data environments Exposure to biologics, omics, sequence data, compound data, imaging data, AI/ML training datasets, or safety/pharmacovigilance data Direct experience operationalizing DOJ EO 14117 or similar US national security data restriction frameworks Experience with privacy-enhancing technologies (pseudonymization, tokenization, synthetic data, federated learning, secure computation) as transfer alternatives Experience with secure research environments, data clean rooms, or federated access architectures as alternatives to full data replication Experience supporting audit preparation, SOP development, or workflow/process redesign Experience in China-facing R&D operations or global roles that required routine coordination on inbound data access for China-based teams Call to Action: If you are motivated to convert complexity into clarity and create the compliant data pathways that fuel next-generation discovery, we would love to hear how you will make this impact with us!Date Posted06-ago.-2026Closing Date13-ago.-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.SummaryLocation: UK - CambridgeType: Full time Read Less
  • Associate Director, Systems Medicine  

    - Cambridge
    Location: The Discovery Center (DISC), Cambridge Biomedical Campus, UK... Read More
    Location: The Discovery Center (DISC), Cambridge Biomedical Campus, UKSalary: Competitive Salary and Benefits!Introduction to the role:Are you ready to turn mechanistic models into dose and schedule strategies that protect patients and accelerate development? Join a team of specialist modelers who operate with high visibility and real decision-making influence, shaping clinical strategy across therapy areas. Based at our Discovery Centre in Cambridge, UK, you will work in a dynamic, multidisciplinary environment spanning nonclinical and clinical phases. About the role:The Systems Medicine group is seeking a Systems Modeler passionate about using mathematical and computational skills to develop and apply empirical and/or mechanistic models of Pharmacology and Toxicology. The group is under Clinical Pharmacology & Quantitative Pharmacology Department and consists of ~20 mathematical modelers with backgrounds in applied biomathematics, computational biology, and/or biomedical/chemical engineering. Working in a dynamic, multidisciplinary environment the successful candidate support projects in both non-clinical and clinical phases. The candidate will develop and apply pharmacological mechanistic systems models to contribute to decisions on dose regimens by balancing efficacy and safety via modelling & simulation based on the understanding of the mechanism of action of investigational drugs. The role will include opportunities to develop and apply Quantitative Systems Pharmacology (QSP) and Toxicology (QST) models, including incorporation of virtual populations to support translational decision-making and dose/schedule selection. In addition, the incumbent will develop QSP&T models based on Microphysiological Systems (organ-on-chips and organoids). To succeed in this role, we believe you have drug development experience and you are a person who enjoys working collaboratively with a variety of key stakeholders and collaborators to identify opportunities, build support and deliver innovative modelling and simulation solutions. Experience or exposure in modalities such as immune cell engagers, antibody-drug conjugates (ADCs), and radioconjugates (RCs) would be valuable. Main responsibilities: Create, expand or refine mathematical models to address drug-discovery and nonclinical/clinical development questions Lead compound-specific projects with hands-on analysis by choosing the best modelling approach to address questions Contribute to the design, execution, and interpretation of clinical studies Develop and apply clinical QSP&T models, including virtual population approaches, to support prediction of efficacy, safety, and dose regimens in clinical development Test and adopt existing modelling platforms Review modelling works by colleagues, ensuring high-quality standards Contribute to AZ drug development with innovative ideas Stay informed with emerging literature and science in modelling and simulation sciences, including developments in clinical QSP&T models, virtual populations, and digital twin approaches Collaborate well within the Systems Medicine group and cross-functional teams Guide junior modelers Represent AZ by publication, podium presentations, and/or organization of symposia Essential requirements: PhD or similar degree in chemical, mechanical or biomedical engineering, physics, applied mathematics or related field Experience working in the industry and postdoctoral experience in building, validating, and using predictive mechanistic mathematical models for drug development. (Ideally, 4 years of experience).At least 3 published papers Excellent understanding of theory, principles and statistical aspects of mathematical modelling and simulation, including numerical methods, parametrization and ODEs. Knowledge of models of biological pathways/systems to support translational research. Hands-on knowledge of modelling with ODEs, Agent-Based Modelling, Statistical and/or Machine Learning modelling, etc Aptitude and experience to influence decisions and experimental design by using available data and appropriate modelling solutions Self-directed, independent, and highly-motivated researcher who excels in a collaborative, multi-disciplinary environment. Evidence of identifying, developing, and applying innovative solutions to scientific and technological problems faced in systems and predictive modelling Familiarity with the challenges of drug discovery and forward thinking with respect to the general application of mathematical models in drug discovery and development Excellent oral and written communication skills and the ability to interact effectively with scientists in other subject areas with a positive and collaborative attitude Experience with data analysis tools and languages such as Matlab and/or Python. Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop models. Ability to keep up to date with and propose the implementation of scientific and technological developments. Ability to interact across pre-clinical and clinical teams. Ability to keep up with new modelling approaches and propose implementation of scientific and technological developments in the areas of QSP&T Experience in linking QSP&T and pharmacokinetics to predict safe and efficacious doses Experience or demonstrated exposure to clinical-stage QSP modelling, ideally including use of virtual populations to characterize variability and support clinical decision-making Preferred Skills and Qualifications Exposure to current principles and concepts in DMPK, Toxicology and Safety Experience with PK, PKPD, TKTD modelling and joint longitudinal modelling tools or any other relevant software. Familiarity with the challenges of drug discovery and forward thinking with respect to the general application of mathematical models in discovery and development. Evidence of identifying, developing, and applying innovative solutions to scientific and technological problems faced in systems and predictive modelling. Experience with clinical QSP&T applications in oncology or related therapeutic areas Experience incorporating virtual populations using mechanistic models Exposure to digital twin concepts or approaches in clinical/translational modelling Experience or familiarity with immune cell engagers, ADCs, radioconjugates (RCs) and/or Microphysiological System data analysis Why AstraZeneca:Here you will be recognized as an expert working at the forefront of science, with the visibility and trust to make consequential decisions for patients and the business. We bring unexpected teams into the same room to unleash bold thinking, blending deep quantitative skills with clinical, biology, and safety expertise. Our environment is both supportive and stretching: leaders back smart risk-taking, and we treat setbacks as data to learn from. You will work across multiple therapy areas, in a fast-growing company investing heavily in data and technology, all while anchoring your impact in a clear purpose—advancing medicines that change lives. We value kindness alongside ambition, and we celebrate work that improves how decisions are made for patients. We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, colour, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.So, what’s next?Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!Where can I find out more?Follow AstraZeneca on LinkedInFollow AstraZeneca on Facebook Follow AstraZeneca on Instagram Date Posted08-Jul-2026Closing Date15-Aug-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.SummaryLocation: UK - CambridgeType: Full time Read Less
  • Cardio Renal Specialist  

    - Leeds
    Cardio Renal SpecialistType: PermanentLocation: Yorkshire, UKCompetiti... Read More
    Cardio Renal SpecialistType: PermanentLocation: Yorkshire, UKCompetitive salary and benefitsIntroduction to roleAre you ready to motivate change in the world of Cardiorenal health? As a Cardio Renal Specialist, you'll play a pivotal role in advancing AstraZeneca's Cardiorenal portfolio. This strategic commercial position involves developing local account plans to enhance treatment and prevention of heart failure (HF) and chronic kidney disease (CKD) through the uptake of our innovative medicines. You'll be responsible for the commercial performance of your accounts, leading market access initiatives, and building strategic relationships with key partners such as Nephrologists, Cardiologists, and Key External Experts. Your efforts will support the transition of care from secondary to primary settings, ensuring that patients receive the best possible outcomes.AccountabilitiesDeliver sales targets for allocated brands.Develop and put into action business plans for the region, showcasing both short- and long-term planning.Establish strong local prescribing advocacy with healthcare professionals and key external experts.Mobilize key external experts to drive positive change in prescribing behaviour among peers.Develop and maintain strong professional relationships with key partners to optimize local patient care for CKD and HF.Ensure local guidelines are updated in line with NICE and integrated into local CKD/HF guidelines.Drive implementation of local guidelines into hospital protocols.Increase awareness and implementation of local formulary and guidelines to ensure optimal patient access.Identify potential barriers to prescribing and work with cross-functional partners to implement aligned action plans.Maintain high levels of clinical, therapy area, and environmental knowledge.Use approved promotional and non-promotional resources to support customer account objectives.Collaborate with broader CVRM field teams to meet customer and business objectives.Implement commercial and project-based offerings as required by the business.Ensure compliance with all governance policies and adherence to the ABPI Code of Practice.Manage budget within +/- 3%.Essential Skills/ExperienceAccount management experience & development of account plansSecondary care sales experienceTrack record of engaging key partners in complex clinical environments, e.g., mid and senior level healthcare professionals, key accounts and the medical communityProven track record in influencing the partner decision-making process in an ecosystem with multiple influential players / decision makers, with proven track record of crafting value in complex DMU or equivalent experienceProven demonstration of successful working in complex cross functional teamsBusiness management, commercial foresight and financially analytical & conversantDemonstrable ability to negotiate at business-to-business levelDesirable Skills/ExperienceCurrent knowledge and experience of AZ designated territory and customersExperience of influencing successfully in a complex organisationProven track record of launching secondary care medicine/worked in an environment with rapidly shifting clinical and treatment paradigmsSales in CVRM productsTherapy Area knowledgeWhen we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.At AstraZeneca, we are driven by a commitment to innovation and excellence. Our Biopharmaceuticals pipeline is expanding, offering exciting opportunities to make a real impact on patient care. We foster an environment where diverse perspectives are valued, encouraging collaboration across teams to solve complex challenges. With a focus on continuous learning and development, you'll have the chance to grow your career while contributing to groundbreaking advancements in healthcare.Ready to take on this exciting challenge? Apply now to join our team and help shape the future of Cardiorenal health!Date Posted31-Jul-2026Closing Date14-Aug-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.SummaryLocation: UK - LeedsType: Full time Read Less
  • Director, Site Management & Monitoring – UK OncologyLocation: Luton (o... Read More
    Director, Site Management & Monitoring – UK OncologyLocation: Luton (onsite 3 days per week)About AstraZenecaAstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.Come and join our AZ team where you will play a pivotal role in this exciting period of development!The Director Site Management & Monitoring (DSMM) is accountable for successfully delivering their portion of the AZ UK Oncology Clinical Trials portfolio according to agreed resources, budget and timelines aligning with AZ Procedural Documents, international guidelines such as ICH-GCP as well as relevant local regulations. The DSMM is responsible for line managing dedicated group(s) of staff and responsible for planning and utilization of staff resources, assigned budget, objective setting and performance follow-up.As assigned, the DSMM is accountable for ensuring that study sites are identified, site qualifications performed, set up, initiated, monitored, closed and documentation archived.Key Responsibilities:Leadership of dedicated group, building the team spirit, developing team style and behaviour.Ensures adequate resources for the studies assigned.Ensures that the workload of direct reports is adequate and responsible for development and performance management of the direct reports according to IDP process.Coaches the direct reports on a regular basis, and plans/organises coaching with external providers if needed.Prepares salary and bonus proposals for direct reports based on their performance in close collaboration with responsible (Senior) Director, Country Head and local HRBP.Contributes to efficient SMM organisation and its functioning at country level by working closely with responsible (Senior) Director, Country Head.Oversees successful delivery of UK SMM clinical trials to plan, with speed and quality.Contributes to the quality improvement of the local processes and other procedures.Provides direction to LSAD/ Local Study Teams on major study commitments including forecasting study timelines, resources, recruitment, study materials and drug supply.Ensures close collaboration with local Medical Affairs team.Ensures that study activities at country level align with local policies and code of ethics.Reviews SQV reports of direct reports in line with AZ SOPsReviews Accompanied site visits/co- monitoring visits/training visits/QC visits performed to direct reports in line with the local QC plans.Performs accompanied site visits according to local QC Plan, supporting ongoing coaching and development.Requirements:Bachelor degree in related field, preferably in life science, or equivalent qualification.Significant years of experience in Clinical Trials (CRA / SrCRA / LSAD) or other related fields.Proven leadership experience managing and developing teams, including coaching, performance management, and building a strong team culture.Experience in study resource planning and workload management to ensure appropriate support for assigned studies.Experience delivering clinical study targets at country level, with a focus on timelines, quality, and operational performance.Experience contributing to study planning and forecasting, including timelines, recruitment, materials, and drug supply.Strong knowledge of the Clinical Study Process and international ICH-GCP guidelines.Manage change with a positive approach for self, team and business. Sees change as an opportunity to improve performance and contribute to business.Excellent organisational, analytical, influencing and negotiation skills.Excellent presentation and communication skills, verbal and written.Desirables: Excellent knowledge of the Monitoring Process.Good knowledge of ICH GCP plus relevant local and international regulations.Ability to learn relevant AZ Therapeutic Areas.Ability to look for and champion more efficient and effective methods/processes of delivering quality clinical trials with reduced budget and in less time.In Office Requirement: When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.Competitive salary and benefits package on offer.The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.Date Posted29-Jul-2026Closing Date12-Aug-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.SummaryLocation: UK - LutonType: Full time Read Less
  • Senior Scientist  

    Title: Senior Scientist, Process Chemistry Location: Macclesfield Remo... Read More
    Title: Senior Scientist, Process Chemistry Location: Macclesfield Remote/Onsite Requirement: Macclesfield – lab-based role 100% onsite Duration of Contract: 12 Months IR35 Determination: INSIDE AstraZeneca is a global, innovation-driven biopharmaceutical company where we not only focus on the discovery, development and delivery of life-saving medicines to our patients but believe in sustainability and are determined to minimise the impact of our work on the environment. We are proud to be a great place to work and have a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity. Chemical Development: In Chemical Development we are determined to push the boundaries of science to deliver medicines to our patients. We combine people’s technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes and processes that deliver the active pharmaceutical ingredients of our medicines in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop. We now have exciting opportunities for Senior Scientists in our growing process chemistry development teams. The responsibilities and requirements of the position are outlined below. Key responsibilities: As a process chemist working closely with analytical chemists, engineers, project managers and other scientists, you will contribute to pharmaceutical development programmes, supporting project progression through late clinical development and launch.Potentially, you will lead significant parts of chemistry development programmes. You will: Design and implement new chemical routes and processes suitable for scale-up, with a focus on process understanding. Be responsible for optimising chemical manufacturing processes taking consideration of speed, quality, cost, sustainability, reproducibility and efficiency Collaborate closely with other scientists to contribute to the development of new medicines. Assess and manage process risks arising from scale, equipment or process changes. Support problem solving when development or manufacturing issues arise. May also work with third party organisations to develop and manufacture API processes. Essential Requirements: A PhD in Organic Chemistry, or BSc/MSc with relevant industrial experience to an equivalent level Substantial experience in practical organic synthesis A proven record of innovation through, for instance, authorship of papers, inventor status on patents, or presenting at external conferences An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques The ability to think innovatively to drive improvement, and address issues when contributing to project strategies Desirable Requirements Lab-based pharmaceutical industry and/or process development experience, using a broad range of practical techniques Practical experience of modern synthetic technologies, e.g. process analytical techniques, continuous processing, high through-put experimentation, etc. The ability to develop and analyse multiple solutions to problems Skills and capabilities Ability to challenge and innovate, bringing new solutions and opportunities for chemical development. Ability to analyse and interpret complex chemistry problems and provide solutions Excellent communication skills, with the ability to communicate across interfaces of scientific disciplines, culture, and expertise both internally and externally. AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. Read Less
  • Business Development and M&A plays a critical core role in AZ achievin... Read More
    Business Development and M&A plays a critical core role in AZ achieving its strategic priority of growth through scientific innovation through the successful execution of transactions which expand, focus and rationalise the Company’s pipeline and portfolio. Recent transaction examples include the acquisition of Fusion Pharmaceuticals and Gracell Biotechnologies, the exclusive license agreements with Eccogene and Dizal Pharmaceuticals, and the collaborations with Daiichi Sankyo and Merck. As the Senior Director in Alliance and Integration Management (AIM) team, you will play a critical role in achieving our strategic priority of growth through scientific innovation. Reporting to the Head of AIM, you will manage and optimize the value of late-phase development/commercial alliances, own the integration of complex partnerships/asset-acquisitions, and lead the transition of divestments across the global business. Through exceptional leadership, strong cross-functional alignment and collaboration with multiple groups (executive leadership, business development, legal, finance, commercial, operations, clinical, regulatory) and the solid building of effective partner relationships, this role ensures cohesive engagement with the overall Alliance and Integration Management performance objectives. Requiring exceptional leadership, strong cross-functional alignment, collaboration with multiple groups (executive leadership, business development, legal, finance, commercial, operations, clinical, regulatory) and the solid building of effective partner relationships, this is a highly visible, impactful role with the opportunity for advancement to many other progressive leadership roles within the company.Accountabilities: Lead the integration and alliance activities for high priority and complex company acquisitions, divestitures, strategic alliances and other deal types through cross-functional teams. Drive the rapid establishment of optimized, efficient business processes for integrated entities and alliance relationships to deliver the value underpinning the business case for the deal, whilst balancing and managing business, legal, and human risks appropriately Own the reporting of progress for the key acquisitions and alliances across AZ to SET and senior stakeholders, recommending areas for performance improvement Ensure compliance with all contractual provisions, managing contractual disputes, and coordinating contract renegotiations or amendments when required. In collaboration with Due Diligence and Transaction Directors, you will provide input and expertise in negotiating the new alliances, divestment transfer service agreements, and ensure seamless transition from signature to the initiation of integration or alliance You will also build and implement best-in-industry approaches to Alliance and Integration Management, developing tools, techniques and processes to improve AstraZeneca's ways of working in delivering integrations and managing successful alliances You will act as a spokesperson / ambassador for AZ at Alliance, Integration and BD meetings and conferecnes, ensuring that AZ is seen as a leader in the field of alliance and integration management Essential: Bachelor's Degree or equivalent experience (business, legal, finance or life sciences discipline) 10+ years' relevant pharmaceutical/biotech industry experience  Desired:  MBA or other post-graduate qualification, CA-AM, CSAP Detailed understanding of contracts, partnerships, negotiation tactics, alliance management and M&A integration. Transition experience including carve-outs, divestitures and developing best practices. Keen understanding of the scientific drug development process, regulatory and commercial concepts, and knowledge of the crucial activities for all key functional areas. Analytical and has the ability to frame complex problems and articulate clear, data-driven recommendations.  Able to analyze problems and provide resolutions at both strategic and tactical levels. Outstanding relationship building, negotiating and interpersonal abilities to connect with individuals across all levels  Ability to build consensus between various internal and external partners, functions and collaborators Date Posted11-Aug-2026Closing Date25-Aug-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.SummaryLocation: UK - CambridgeType: Full time Read Less
  • Introduction to roleAre you ready to turn complex cross-border data ru... Read More
    Introduction to roleAre you ready to turn complex cross-border data rules into practical pathways that unlock AI-driven drug discovery? Do you thrive at the intersection of scientific data, regulatory interpretation, and operational execution where your decisions enable researchers to move faster with confidence?About the Beijing AI Center The Beijing AI Center is a new strategic investment by AstraZeneca to accelerate drug discovery through AI. The center brings together AI researchers, computational scientists, and platform engineers to apply foundation models, agentic AI, and large-scale scientific computing to real R&D problems. Situated in one of the world’s most dynamic AI talent markets, it operates at the intersection of biologics discovery, computational chemistry, and AI-driven drug discovery. The center is structured around three pillars: Discovery verticals (therapeutic design and preclinical predictions), Data & AI Platforms, and Ecosystem Partnerships with leading Chinese academic institutions and AI companies. Accountabilities:This role is the transfer-readiness owner for enabling cross-border scientific data access into China for the Beijing AI Center. It addresses the operational gap that exists before formal approval:the preparation work needed to ensure incoming data requests are assessed against sending-jurisdiction restrictions, appropriately scoped, decision-ready, and auditable. The primary data flow is global AstraZeneca R&D into China. The Beijing AI Center needs access to molecular libraries, assay data, omics reference sets, compound data, clinical datasets, and other scientific assets from AstraZeneca's global portfolio to power AI-driven drug discovery. The regulatory challenge sits largely on the sending side — determining what can be transferred or accessed given restrictions(e.g., DOJ EO 14117) on bulk sensitive personal data, export control considerations, and AstraZeneca's internal data governance policies — as well as ensuring appropriate classification and protection once data arrives in China. This is not a final approver role. Rather, it is a dedicated role focused on first-pass triage, provenance tracing, metadata review, annotation coordination, evidence package preparation, and process tracking. The role is intended to reduce the fragmented burden currently carried in an ad hoc way by scientists, business teams, and SMEs, especially for China-related or otherwise non-standard requests. The immediate priority is China data transfer, but the role should be designed for broader global cross-border sharing. The role will help stabilize the current interim process while building a more scalable and consistent operating model that can inform a future integrated solution. This role sits at the intersection of scientific data, compliance preparation, and operational execution. It requires enough breadth across R&D data domains and cross border transfer regulations to work effectively across biologics, small molecules, and safety-related contexts, while also knowing when to pull in domain SMEs, the R&D Data Office, Privacy, Compliance, and designated approvers. What You Will Do Transfer Readiness & First-Pass Triage Design and own the intake process for cross-border data sharing requests — including request workflow, queue management, prioritization criteria, and routing logic Own first-pass intake triage for cross-border data sharing requests, with mandatory review for China-related or non-standard requests and simplified routing for straightforward requests Check request completeness including business justification, recipient, intended use, data source, format, and baseline supporting information Provide first-pass triage recommendation on whether a request is likely in scope, out of scope, or ambiguous, while preparing the supporting rationale for formal review Escalate ambiguous or higher-risk cases to the R&D Data Office, SMEs, and designated approvers with clear questions and structured evidence Manage DOJ compliance assessment for CRO ordering — evaluating data shared with China-based CROs against EO 14117 thresholds and transaction type classifications Provenance Tracing, Annotation & Metadata Coordination Lead provenance tracing for legacy or incompletely documented datasets by reviewing records, systems, and source history across relevant platforms Coordinate metadata collection and completion needed to support transfer assessment and downstream usability Support annotation and evidence preparation so datasets are sufficiently described, contextualized, and auditable before review Partner with bioinformatics and scientific SMEs to resolve data history, source, ownership context, and metadata gaps Differentiate between new / well-annotated data and legacy / incomplete data, applying a lighter path for the former and a deeper tracing effort for the latter Data Curation & China-Readiness Curate and annotate scientific data assets (e.g., structure data in GDB) to ensure datasets are complete, well-structured, and usable for Beijing AI Center workstreams  Perform structure data curation supporting both Biologics Engineering and Small Molecules domains  Apply appropriate ontologies, standardized formats, and metadata tagging to support cross-domain reuse and AI/ML consumption  Partner with domain scientists to resolve data quality, completeness, and annotation gaps prior to transfer Workflow Management & Process Improvement Prepare structured evidence packages for Data Owners, Data Stewards, and designated approvers so requests are decision-ready before formal review Track the interim data sharing process from intake through approval, transfer execution, validation, and closure Act as process coordinator / tracker during transfer execution, following up on dependencies and ensuring documentation is complete, without taking over technical execution tasks Capture recurring issues, requirements, and control points from the interim process to support the design of a future integrated data sharing solution Improve templates, checklists, trackers, SOP inputs, and audit-readiness practices over time Cross-Functional Partnership & Training Work with the R&D Data Office to identify what data is likely in scope or out of scope across different workstreams Partner with Privacy and Compliance to ensure transfer assessments reflect current privacy requirements and that escalation pathways are well-defined Build practical understanding of the systems used across biologics, small molecules, and safety and how data is stored, annotated, accessed, and extracted from separate systems Provide guidance to business and scientific teams on transfer readiness expectations, required metadata, and supporting information Reduce ad hoc burden on scientists and business teams by becoming the clear owner of the manual preparation work needed before approval Essential Skills/Experience:Education: BSc/MSc, or equivalent advanced training in life sciences, bioinformatics, data science, information management, or a related field preferred Years: Significant experience in pharmaceutical or biotech R&D data environments, typically 4+ years post-qualification Domain breadth: Experience spanning multiple stages of drug discovery and development and/or multiple scientific data domains (e.g., discovery, preclinical, clinical, post-market) Core expertise: Practical experience in one or more of: scientific data management, data stewardship, data governance, research data operations, data privacy operations, or regulated data workflows Cross-border data work: Experience assessing, preparing, or supporting cross-border data sharing decisions — particularly understanding sending-side regulatory requirements and how to structure compliant access Governance preparation: Experience preparing information for governance, compliance, or approval decisions — not only executing downstream data processing Skills Regulatory literacy: Ability to understand and operationalize requirements from multiple regulatory frameworks (US DOJ, internal policy) at a working level — sufficient to perform first-pass assessment and know when to escalate to Legal DOJ EO 14117 familiarity: Working understanding of the DOJ's bulk sensitive personal data framework — including threshold categories, covered transaction types, prohibited vs. restricted classifications, and exemption pathways — is strongly preferred Domain-specific data skills: Familiarity with structural biology/chemistry data, molecular data formats, and scientific annotation standards (e.g., structure-activity relationships, compound descriptors, GDB or equivalent platforms) Domain versatility: Ability to work across biologics, small molecules, clinical, omics, imaging, and safety-related data contexts with enough breadth to assess data content and origin Analytical rigor: Ability to assess data volumes against thresholds, map data to jurisdictions, evaluate exemption applicability, and structure clear decision-support documentation Operational discipline: Strong documentation rigor, process discipline, and audit mindset Stakeholder management: Credibility across scientists, AI researchers, SMEs, legal/privacy teams, and governance approvers — able to translate between technical data needs and compliance requirements Problem-solving: Ability to identify alternative access patterns, minimization strategies, and creative solutions when straightforward transfer is restricted Systems literacy: Enough familiarity with data platforms to understand how data is stored, what metadata exists, and how to assess data content without requiring deep technical data engineering skills China / Cross-Border Context China data classification: Familiarity with China's DSL data classification framework and what obligations apply to data once it enters China is preferred Global matrixed environment: Ability to work effectively across China and non-China stakeholders — coordinating with US, EU/UK, and global teams on data access requests Mindset Comfortable with ambiguity: Regulatory frameworks are evolving (particularly DOJ implementation guidance); this role will often work with emerging interpretations, grey areas, and imperfect precedent Low ego, high impact: Willing to do detailed threshold calculations, jurisdiction mapping, and documentation work that enables better decisions at scale Enablement-oriented: Approaches compliance as a problem to solve, not a gate to close — actively seeks minimization strategies, alternative access patterns, and creative compliant solutions to get researchers what they need Structured and practical: Able to turn regulatory requirements and fragmented information into a clear, repeatable operating process Collaborative and credible: Able to work across scientific, AI, legal, privacy, and governance stakeholders with equal fluency Judicious and disciplined: Understands the difference between first-pass triage and final approval accountability Time zone flexibility: Comfortable working across US/UK and China hours as needed to support Beijing AI Center stakeholders Desirable Skills/Experience:Education: PhD within relevant field Experience in both discovery-stage and later-stage R&D data environments Exposure to biologics, omics, sequence data, compound data, imaging data, AI/ML training datasets, or safety/pharmacovigilance data Direct experience operationalizing DOJ EO 14117 or similar US national security data restriction frameworks Experience with privacy-enhancing technologies (pseudonymization, tokenization, synthetic data, federated learning, secure computation) as transfer alternatives Experience with secure research environments, data clean rooms, or federated access architectures as alternatives to full data replication Experience supporting audit preparation, SOP development, or workflow/process redesign Experience in China-facing R&D operations or global roles that required routine coordination on inbound data access for China-based teams Call to Action: If you are motivated to convert complexity into clarity and create the compliant data pathways that fuel next-generation discovery, we would love to hear how you will make this impact with us!Date Posted06-ago.-2026Closing Date13-ago.-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.SummaryLocation: UK - CambridgeType: Full time Read Less
  • Procurement Director - Energy & Utilities  

    - Cheshire East
    Introduction to role:Are you ready to steer how AstraZeneca secures an... Read More
    Introduction to role:Are you ready to steer how AstraZeneca secures and optimises its energy to accelerate progress to net zero while safeguarding resilience across the UK and EMEA? Can you turn volatile markets and regulatory change into stable budgets, credible decarbonisation and long-term value?Reporting to the Senior Director, Infrastructure, you will own our UK energy sourcing strategy and influence our wider portfolio, ensuring reliable, compliant and cost-effective supply across electricity, gas and related utility categories. Your work will power our labs, manufacturing and offices, enabling science to move faster from discovery to patients. You will partner closely with collaborators at AZ sites in Macclesfield, Cambridge and Speke, shaping global category strategies that translate into local execution, and then channelling site insight back into strategy.This is a visible, high-impact role in a collaborative, fast-moving environment where data, market intelligence and focused governance underpin bold decisions. You will blend strategic procurement, energy market expertise and interested party engagement to deliver commercial value, reduce risk and hit decarbonisation milestones—while building supplier relationships that unlock innovation.Accountabilities:Strategy Deployment: Lead the rollout and execution of energy and utilities procurement strategies across the UK and into EMEA, aligning with site priorities and global directions to deliver measurable productivity, resilience and emissions progress.Value Delivery: Identify, shape and deliver value opportunities spanning cost, cash, risk and innovation—progressing from quick wins to multi-year levers including PPAs and portfolio optimisation.Category Strategy & Sourcing: Define and maintain the UK energy category strategy for electricity, natural gas and related services (capacity, balancing, green products, REGO/GoO, bio methane certificates); run sourcing events, negotiate supply agreements and optimise structures (flex vs fixed, pass-throughs, index linkages) for total value.End-to-End Sourcing: Own sourcing strategy, supplier selection, commercial negotiations and contract implementation with clear benefits cases, timelines and governance.Supplier Performance Management: Govern performance through SLAs, critical metrics and continuous improvement; resolve issues at root cause and prevent recurrence.Supplier Relationship Management: Establish SRM that drives innovation, service and operational performance with utilities, TPIs/brokers, generators and flexibility providers.Risk Management & Hedging: Build and operate an energy risk framework aligned to corporate appetite; implement hedges, handle open positions against budget and report mark-to-market exposure, VaR and compliance with limits.Market Intelligence: Track UK and European markets (power, gas, carbon, Guarantees of Origin, capacity, network charges) and regulatory change (Ofgem, National Grid ESO/NGN/NGG, BEIS/DESNZ), translating insight into cost, risk and sustainability actions.Contract & Supplier Management: Oversee contract performance, billing accuracy and credit terms; handle disputes and drive value initiatives.Regulatory & Compliance: Ensure compliance with UK energy regulations and reporting obligations (ESOS, SECR, P272/P302, half-hourly metering, DUoS/TNUoS/BSUoS pass-throughs); coordinate with Legal and Compliance on terms, sanctions and counterparty risk.Sustainability & Decarbonisation: Deliver net zero and science-based targets via credible renewable procurement (onsite and offsite PPAs, sleeved/virtual PPAs, REGO strategy), bio methane/green gas and demand-side flexibility; validate additionally and claims in line with UK guidance.Data, Forecasting & Budgeting: Own demand forecasting, budgeting and variance analysis; validate invoices, reconcile non-commodity charges and ensure data integrity; drive continuous improvement in data and reporting, using Excel/Power BI and relevant platforms.Flexibility & Optimisation: Identify and contract demand response, storage and optimisation opportunities (DSR, Triad/BSUoS considerations, DUoS red-band management) in partnership with engineering and site teams.Stakeholder Engagement: Partner with Finance, Sustainability, Engineering, Operations and Real Estate to align sourcing, risk and sustainability; communicate market movements, risk positions and budget impacts to senior leaders.Governance & Reporting: Maintain procurement controls, tender governance and audit trails; produce periodic reports on spend, risk, savings, emissions attributes and supplier performance.Sustainability and Responsible Sourcing: Embed environmental and social responsibility in strategies, engagements and contracts.Governance and Compliance: Adhere to procurement policies and governance requirements while delivering operational excellence and business outcomes.Safety, Health and Environment: Promote a culture of no hurt, harm or alarm; proactively identify hazards and act.Ethical Conduct: Align with internal and external regulations and the Code of Ethics; complete training and raise potential non-compliance.Delivery and Cost Focus: Maintain high service levels and instil a cost-conscious culture that sharpens total cost of ownership.Lean and Standardised Ways of Working: Apply disciplined, standardised processes and lean principles to increase speed and reliability.Essential Skills/Experience:Education: Degree or equivalent experience in engineering, economics, finance, business, or a related field; MCIPS or progress towards CIPS is preferred.Experience: Significant experience in UK energy procurement or trading, with a track record managing electricity and gas portfolios for large multisite or industrial users. Experience with PPAs and renewable instruments is mandatory with working knowledge of 24/7 matching preferred.Technical Skills: Strong grasp of UK energy market structures, non commodity cost components, network charging methodologies, settlement processes, and metering. Familiarity with hedging instruments and risk frameworks.Commercial & Analytical Skills: Advanced negotiation, category management, and supplier performance management. Proficient in quantitative analysis, forecasting, and scenario modelling; strong Excel/Power BI skills.Regulatory Knowledge: Understanding of Ofgem frameworks, DESNZ policy direction, ESOS/SECR, and relevant sustainability reporting standards.Behavioural Competencies: problem solving, resilience under volatility, clear written and verbal communication with validated ability to influence & negotiate, and a continuous improvement attitude.Desirable Skills/Experience:Experience structuring physical or virtual PPAs in the UK market, including credit and balancing considerations.Knowledge of carbon accounting for purchased energy (e.g., market based vs. location based Scope 2).Exposure to demand side flexibility, battery storage, CHP, or onsite renewables.Experience with eSourcing platforms, EMS/IoT data platforms, and invoice validation tools.Professional certifications related to energy or risk (e.g., AEE, PRM/FRM fundamentals).Knowledge and experience in energy and utilities procurementTechnical expertise in energy hedging methodologiesContract negotiation – analytical and market insight capabilityWhen we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.Why AstraZeneca:Here, sourcing decisions shape how rapidly our science reaches patients and how responsibly we operate. You will join a global, trusted team that connects diverse experts across engineering, finance, sustainability and operations to turn complex markets into decisive action. We bring different perspectives into the same room to spark bold ideas, and we back them with world-class tools, robust data and clear governance. Expect an environment that values kindness alongside ambition, where you can lead at the negotiation table, influence strategy at scale and see your work cut emissions, reduce risk and create tangible value for a company committed to improving health worldwide.If you are interested in this unique opportunity - apply today!Date Posted31-Jul-2026Closing Date16-Aug-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.SummaryLocation: UK - MacclesfieldType: Full time Read Less
  • Senior Applied AI & ML Engineer - Evinova  

    - Greater London
    It currently takes over 10 years and $1.3B to develop a drug. More tha... Read More
    It currently takes over 10 years and $1.3B to develop a drug. More than 70% of that investment goes into clinical trials, yet only ~10% of candidates make it from Phase I to approval. Evinova - a new health-tech business within the AstraZeneca Group—is here to change the math. We use advanced algorithms and GenAI to aim high: boosting clinical trial success by 20%, cutting development time by 3 years, and halving study costs.As Senior Applied AI&ML Engineer, you will prototype and build the systems that make those targets real - blending scientific knowledge, ML and agentic systems to drive transparent and actionable recommendations. You’ll integrate multi‑source data - historical trials and scientific datasets into production systems to improve the process of designing clinical trials and increase their probability of success.If you're motivated by meaningful problems and comfortable working outside your existing experience, you'll thrive here. We're looking for generalists with scientific backgrounds and some software, data science and ML skills — people who are genuinely curious and think scientifically, committed to continuous learning, and eager to rethink how clinical trials are designed. We value people who build with depth and intention, not just wrap LLM API calls.What You'll Bring:FoundationPh.D. or equivalent professional experience in a relevant scientific or quantitative field with industrial experience (Bioinformatics, Mathematics, Computer Science, Machine Learning, Statistics, or similar)Previous industry experience building applied ML/AI systems that have shipped as part of a product and driven measurable business impact.Domain knowledge - familiarity with drug development, clinical trial design, or real-world data (EHR, claims, prescriptions)Machine Learning & AIExperience of classical ML and NLPHands-on work with generative AI – including prompt engineering, context engineering and multiagent systems and working with managed endpoints (OpenAI, Anthropic, AWS Bedrock) and open-weight models (Hugging Face ecosystem)Knowledge of agentic design patterns - planning, memory, tool use/function calling, RAG - with practical experience in evaluation and guardrails appropriate for regulated environmentsExperience working with scientific datasets/ literature.Engineering & DeliveryStrong Python development skills with production sensibilities (testing, observability, documentation)Experience with containers, APIs, and async services (Docker, FastAPI) and CI/CD pipelines (GitHub Actions)Awareness of architectural patterns in deploying applied ML/AI systems in cloud (AWS).Communication & CollaborationAbility to translate complex technical work into clear narratives for both technical and non-technical stakeholdersExperience sharing knowledge with peers and contributing to engineering and data science standards and best practices.Nice to Have:RAG pipelines at depth - experience building secure, compliant ingestion and retrieval systems with provenance tracking, including web automation, parsing, and document processingAgent frameworks - hands-on experience with multi-agent orchestration tools (e.g., Google ADK, StrandsAgents, LangGraph, CrewAI, or equivalents)AI-augmented development - effective use of agentic coding assistants (Copilot, Cursor, Claude Code) to accelerate deliveryOpen source or community contributions - published packages, conference talks, or internal framework developmentStartup-pace experience - comfort with ambiguity, rapid iteration, and wearing multiple hatsLocation: St Pancras London (3 days per week onsite / 60% overall)Salary: Competitive + Excellent Benefits!Why Evinova (AstraZeneca)?Evinova draws on AstraZeneca’s deep experience developing novel therapeutics, informed by insights from thousands of patients and clinical researchers. Together, we can accelerate the delivery of life-changing medicines, improve the design and delivery of clinical trials for better patient experiences and outcomes, and think more holistically about patient care before, during, and after treatment.  We know that regulators, healthcare professionals, and care teams at clinical trial sites do not want a fragmented approach. They do not want a future where every pharmaceutical company provides its own, different digital solutions. They want solutions that work across the sector, simplify their workload, and benefit patients broadly. By bringing our solutions to the wider healthcare community, we can help build more unified approaches to how we all develop and deploy digital technologies, better serving our teams, physicians, and ultimately patients. Evinova represents a unique opportunity to deliver meaningful outcomes with digital and AI to serve the wider healthcare community and create new standards for the sector.  Join us on our journey of building a new kind of health tech business to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting-edge methods, and bringing unexpected teams together. Interested? Come and join our journey.Where can I find out more?Learn more about Evinova: Follow Evinova on LinkedIn: When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.#LI-HYBRIDDate Posted11-Aug-2026Closing Date25-Aug-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.SummaryLocation: UK - LondonType: Full time Read Less
  • Senior Scientist  

    p strong Title: /strong Senior Scientist, Process Chemistry /p p stron... Read More
    p strong Title: /strong Senior Scientist, Process Chemistry /p p strong Location: /strong Macclesfield /p p strong Remote/Onsite Requirement: /strong Macclesfield – lab-based role 100% onsite /p p strong Duration of Contract: /strong 12 Months /p p strong IR35 Determination: /strong INSIDE /p p br /p p AstraZeneca is a global, innovation-driven biopharmaceutical company where we not only focus on the discovery, development and delivery of life-saving medicines to our patients but believe in sustainability and are determined to minimise the impact of our work on the environment. We are proud to be a great place to work and have a culture that inspires innovation and collaboration. We empower our colleagues to express diverse perspectives and at the same time feel valued, respected and rewarded for their ideas and creativity. /p p br /p p strong Chemical Development: /strong /p p In Chemical Development we are determined to push the boundaries of science to deliver medicines to our patients. We combine people’s technical knowledge and understanding with their talent and drive to design, develop and optimise synthetic routes and processes that deliver the active pharmaceutical ingredients of our medicines in a sustainable, commercially viable way. We believe in innovation and continuous improvement, working closely with colleagues in academia and across industry, to ensure that we apply the newest technologies and principles in the processes we develop. /p p br /p p We now have exciting opportunities for Senior Scientists in our growing process chemistry development teams. The responsibilities and requirements of the position are outlined below. /p p br /p p strong Key responsibilities: /strong /p p As a process chemist working closely with analytical chemists, engineers, project managers and other scientists, you will contribute to pharmaceutical development programmes, supporting project progression through late clinical development and launch.Potentially, you will lead significant parts of chemistry development programmes. You will: /p ul li Design and implement new chemical routes and processes suitable for scale-up, with a focus on process understanding. /li li Be responsible for optimising chemical manufacturing processes taking consideration of speed, quality, cost, sustainability, reproducibility and efficiency /li li Collaborate closely with other scientists to contribute to the development of new medicines. /li li Assess and manage process risks arising from scale, equipment or process changes. /li li Support problem solving when development or manufacturing issues arise. /li li May also work with third party organisations to develop and manufacture API processes. /li /ul p br /p p strong Essential Requirements: /strong /p ul li A PhD in Organic Chemistry, or BSc/MSc with relevant industrial experience to an equivalent level /li li Substantial experience in practical organic synthesis /li li A proven record of innovation through, for instance, authorship of papers, inventor status on patents, or presenting at external conferences /li li An excellent understanding of synthetic reagents and methodologies, reaction mechanisms and modern analytical techniques /li li The ability to think innovatively to drive improvement, and address issues when contributing to project strategies /li /ul p br /p p strong Desirable Requirements /strong /p ul li Lab-based pharmaceutical industry and/or process development experience, using a broad range of practical techniques /li li Practical experience of modern synthetic technologies, e.g. process analytical techniques, continuous processing, high through-put experimentation, etc. /li li The ability to develop and analyse multiple solutions to problems /li /ul p br /p p strong Skills and capabilities /strong /p ul li Ability to challenge and innovate, bringing new solutions and opportunities for chemical development. /li li Ability to analyse and interpret complex chemistry problems and provide solutions /li li Excellent communication skills, with the ability to communicate across interfaces of scientific disciplines, culture, and expertise both internally and externally. /li /ul p br /p p em AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. /em /p Read Less

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Astrid-Lindgren-Weg 12 38229 Salzgitter Germany